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Article

A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.

The Journal of biological chemistry - 16 Jul 2010

Dresen Carola, Lin Leo Y-C, D'Angelo Igor, Tocheva Elitza I, Strynadka Natalie, Eltis Lindsay D

Abstract excerpt

Mycobacterium tuberculosis (Mtb) and Rhodococcus jostii RHA1 have similar cholesterol catabolic pathways. This pathway contributes to the pathogenicity of Mtb. The hsaAB cholesterol catabolic genes have been predicted to encode the oxygenase and reductase, respectively, of a flavin-dependent mono-oxygenase that hydroxylates 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to a catechol. An hsaA...

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Identifiers

PMID: 20448045
DOI: 10.1074/jbc.M109.099028
PMCID: PMC2903365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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