Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.

Infection and immunity - 1 Jan 2010

Nesbitt Natasha M, Yang Xinxin, Fontán Patricia, Kolesnikova Irina, Smith Issar, Sampson Nicole S, Dubnau Eugenie

Abstract excerpt

Mycobacterium tuberculosis, the causative agent of tuberculosis, is an intracellular pathogen that shifts to a lipid-based metabolism in the host. Moreover, metabolism of the host lipid cholesterol plays an important role in M. tuberculosis infection. We used transcriptional profiling to identify genes transcriptionally regulated by cholesterol and KstR (Rv3574), a TetR-like repressor. The fadA5 (Rv3546) gene,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androstadienes
Share to Cholesterol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Gene Expression Regulation, Enzymologic

Share to Mycobacterium tuberculosis

Share to Transcription, Genetic

Share to Tuberculosis

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 19822655
DOI: 10.1128/IAI.00893-09
PMCID: PMC2798224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.PMID 19822655Read ↗

A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into <i>Mycobacterium tuberculosis</i> survival in macrophagesSemantic proximity Read ↗

Cholesterol metabolism: a potential therapeutic target in MycobacteriaSemantic proximity Read ↗

The Actinobacterial mce4 Locus Encodes a Steroid TransporterSemantic proximity Read ↗

Clinical strains of Mycobacterium tuberculosis exhibit differential lipid metabolism-associated transcriptome changes in in vitro cholesterol and infection modelsSemantic proximity Read ↗

Pathogen roid rage: Cholesterol utilization by<i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.Semantic proximity Read ↗

Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.Semantic proximity Read ↗

Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis.Semantic proximity Read ↗

ChoD and HsdD can be dispensable for cholesterol degradation in mycobacteria.Semantic proximity Read ↗

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.Semantic proximity Read ↗

The Steroid Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is Important for Pathogenesis and a Target for Vaccine DevelopmentSemantic proximity Read ↗

Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.