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The Actinobacterial mce4 Locus Encodes a Steroid Transporter

28 Oct 2008

Abstract excerpt

Bioinformatic analyses have suggested that Mce proteins in diverse actinobacteria are components of complex ATP-binding cassette transporter systems, comprising more than eight distinct proteins. In Mycobacterium tuberculosis, these proteins are implicated in interactions of this deadly pathogen with its human host. Here, we provide direct evidence that the Mce4 system of Rhodococcus jostii RHA1 is a steroid...

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PMID: 18955493
DOI: 10.1074/jbc.m805496200

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