Article
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
PLoS pathogens - 1 Mar 2009
Yam Katherine C, D'Angelo Igor, Kalscheuer Rainer, Zhu Haizhong, Wang Jian-Xin, Snieckus Victor, Ly Lan H, Converse Paul J, Jacobs William R, Strynadka Natalie, Eltis Lindsay D
Abstract excerpt
Mycobacterium tuberculosis, the etiological agent of TB, possesses a cholesterol catabolic pathway implicated in pathogenesis. This pathway includes an iron-dependent extradiol dioxygenase, HsaC, that cleaves catechols. Immuno-compromised mice infected with a DeltahsaC mutant of M. tuberculosis H37Rv survived 50% longer than mice infected with the wild-type strain. In guinea pigs, the mutant disseminated more...
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