Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AGO2, RDR2, and HEN1 comprise a non-canonical DCL4-mediated antiviral pathway independent of DRB4.

Plant physiology - 6 May 2026

Fu Yan, Zhang Chunwei, Xu Yun, Ruan Mengbin, Ren Yanli, Wu Kunxin, Zhang Xiuchun

Abstract excerpt

Plants employ multiple, redundantly acting Dicer enzymes in a layered antiviral defense system. While Dicer-like 4 (DCL4), aided by its cofactor dsRNA-binding protein 4 (DRB4), serves as the primary antiviral Dicer, the genetic architecture and effector components of its DRB4-independent activity have remained enigmatic. Here, through systematic genetic analysis in Arabidopsis (Arabidopsis thaliana), we delineate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arabidopsis Proteins
Share to Argonaute Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Gene Expression Regulation, Plant

Share to Plant Diseases

Share to Ribonuclease III

Share to RNA-Binding Proteins

Share to RNA-Dependent RNA Polymerase

Source

Identifiers

PMID: 41926706
DOI: 10.1093/plphys/kiag175

Genes

AGO2
AGO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AGO2, RDR2, and HEN1 comprise a non-canonical DCL4-mediated antiviral pathway independent of DRB4.PMID 41926706Read ↗

Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1.Semantic proximity Read ↗

Hierarchical action and inhibition of plant Dicer-like proteins in antiviral defense.Semantic proximity Read ↗

The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative argonautes in Arabidopsis thaliana.Semantic proximity Read ↗

Evidence for an RNAi-independent role of Arabidopsis DICER-LIKE2 in growth inhibition and basal antiviral resistance.Semantic proximity Read ↗

Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing.Semantic proximity Read ↗

Dicer-like2b suppresses the wiry leaf phenotype in tomato induced by tobacco mosaic virus.Semantic proximity Read ↗

Characterization of DCL4 missense alleles provides insights into its ability to process distinct classes of dsRNA substrates.Semantic proximity Read ↗

A Genetic Screen for Impaired Systemic RNAi Highlights the Crucial Role of DICER-LIKE 2.Semantic proximity Read ↗

Novel DICER-LIKE1 siRNAs Bypass the Requirement for DICER-LIKE4 in Maize Development.Semantic proximity Read ↗

Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs.Semantic proximity Read ↗

Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection.Semantic proximity Read ↗

Broad-scale phenotyping in Arabidopsis reveals varied involvement of RNA interference across diverse plant-microbe interactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.