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Article

Protein kinase C-beta gene variants, pathway activation, and enzastaurin activity in lung cancer.

Clinical lung cancer - 1 May 2010

Lee Sang-Haak, Chen Tingan, Zhou Jun, Hofmann Jennifer, Bepler Gerold

Abstract excerpt

BACKGROUND: Protein kinase C-beta2 (PKCbeta2) is a splice-variant of the PRKCB1 gene and belongs to a family of serine/threonine-specific kinases that are predominantly activated by diacylglycerol, calcium, and phorbol ester. Cellular functions associated with PKCbeta2 activation include transfor...

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Identifiers

PMID: 20439192
DOI: 10.3816/CLC.2010.n.021
PMCID: PMC3171168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20439192-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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