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Article

Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.

Cancer research - 1 Apr 2011

Naylor Tara L, Tang Huaping, Ratsch Boris A, Enns Andreas, Loo Alice, Chen Liqing, Lenz Peter, Waters Nigel J, Schuler Walter, Dörken Bernd, Yao Yung-Mae, Warmuth Markus, Lenz Georg, Stegmeier Frank

Abstract excerpt

The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) correlates with poor prognosis. The ABC subtype of DLBCL is associated with constitutive activation of the NF-κB pathway, and oncogenic lesions have been identified in its regulators, including CARD11/CARMA1 (caspase recruitment domain-containing protein 11), A20/TNFAIP3, and CD79A/B. In this study, we offer evidence of therapeutic...

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Share to CARD Signaling Adaptor Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21324920
DOI: 10.1158/0008-5472.CAN-10-2525

Genes

CARD11
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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