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Article

DNA-PKcs as an upstream mediator of OCT4-induced MYC activation in small cell lung cancer

26 Apr 2023

Abstract excerpt

Small cell lung cancer (SCLC) is a neuroendocrine tumor noted for the rapid development of both metastases and resistance to chemotherapy. High mutation burden, ubiquitous loss of TP53 and RB1, and a mutually exclusive amplification of MYC gene family members contribute to genomic instability and make the development of new targeted agents a challenge. Previously, we reported a novel OCT4-induced MYC...

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PMID: 37116859
DOI: 10.1016/j.bbagrm.2023.194939

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