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DNA gyrase and topoisomerase IV mutations in an in vitro fluoroquinolone-resistant Coxiella burnetii strain.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jun 2010

Vranakis Iosif, Sandalakis Vassilios, Chochlakis Dimosthenis, Tselentis Yannis, Psaroulaki Anna

Abstract excerpt

The etiological agent of Q fever, Coxiella burnetii, is an obligate intracellular bacterium that multiplies within a vacuole with lysosomal characteristics. Quinolones have been used as an alternative therapy for Q fever. In this study, quinolone-resistance-determining regions of the genes coding for DNA gyrase and topoisomerase IV were analyzed by DNA sequencing from an in vitro fluoroquinolone-resistant C....

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Identifiers

PMID: 20438350
DOI: 10.1089/mdr.2010.0015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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