Article
Sequencing of gyrase and topoisomerase IV quinolone-resistance-determining regions of Chlamydia trachomatis and characterization of quinolone-resistant mutants obtained In vitro.
Antimicrobial agents and chemotherapy - 1 Oct 1998
Dessus-Babus S, Bébéar C M, Charron A, Bébéar C, de Barbeyrac B
Abstract excerpt
The L2 reference strain of Chlamydia trachomatis was exposed to subinhibitory concentrations of ofloxacin (0.5 microg/ml) and sparfloxacin (0.015 microg/ml) to select fluoroquinolone-resistant mutants. In this study, two resistant strains were isolated after four rounds of selection. The C. trachomatis mutants presented with high-level resistance to various fluoroquinolones, particularly to sparfloxacin, for...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- Chlamydia trachomatis
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Genes, Bacterial
- Molecular Sequence Data