Article
The effect of polymorphisms in the promoter region of the MMP-1 gene on the occurrence and invasiveness of hypophyseal adenoma.
Acta neurochirurgica - 1 Sept 2010
Altaş Murat, Bayrak Omer Faruk, Ayan Erdogan, Bolukbasi Fatihhan, Silav Gokalp, Coskun Kerim Kenan, Culha Mustafa, Sahin Fikrettin, Sevli Serhat, Elmaci Ilhan
Abstract excerpt
BACKGROUND: The matrix metalloproteinase-1 enzyme (MMP-1, also called collagenase 1) plays a key role in turnover of collagen fibers in the intercellular matrix. Insertion of a guanine residue was found within the promoter region of the MMP-1 gene. We found that MMP-1 levels increased approximate...
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