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Article

Clinical significance of a single nucleotide polymorphism and allelic imbalance of matrix metalloproteinase-1 promoter region in prostate cancer.

Oncology reports - 1 Sept 2009

Tsuchiya Norihiko, Narita Shintaro, Kumazawa Teruaki, Inoue Takamitsu, Ma Zhiyong, Tsuruta Hiroshi, Saito Mitsuru, Horikawa Yohei, Yuasa Takeshi, Satoh Shigeru, Ogawa Osamu, Habuchi Tomonori

Abstract excerpt

Matrix metalloproteinase-1 (MMP-1) is associated with cancer invasion and metastasis. The 2G allele of the polymorphic site in the MMP-1 promoter was demonstrated to have a higher transcription activity than the 1G allele. Allelic imbalance (AI) at 11q22 harboring the MMP-1 is frequently observed in various cancers and may be associated with an advanced disease. We conducted a case-control study to determine the...

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Identifiers

PMID: 19639194
DOI: 10.3892/or_00000462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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