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PCR-free MDR1 polymorphism identification by gold nanoparticle probes.

Analytical and bioanalytical chemistry - 1 Jul 2010

Yang Bing, Zhou Guohua, Huang Lequn Lee

Abstract excerpt

Single nucleotide polymorphisms (SNPs) represent the most abundant source of genetic variation in the human genome, and they can be linked to genetic susceptibilities or varied pharmaceutical responses. Established SNP detection techniques are mainly PCR-based, which means that they involve complex, labor-intensive procedures, are easy contaminated, and can give false-positive results. Therefore, we have...

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PMID: 20437224
DOI: 10.1007/s00216-010-3750-4

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