Article
SNP identification in unamplified human genomic DNA with gold nanoparticle probes.
Nucleic acids research - 19 Jan 2005
Bao Y Paul, Huber Martin, Wei Tai-Fen, Marla Sudhakar S, Storhoff James J, Müller Uwe R
Abstract excerpt
Single nucleotide polymorphisms (SNPs) comprise the most abundant source of genetic variation in the human genome. SNPs may be linked to genetic predispositions, frank disorders or adverse drug responses, or they may serve as genetic markers in linkage disequilibrium analysis. Thus far, established SNP detection techniques have utilized enzymes to meet the sensitivity and specificity requirements needed to...
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