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Article

GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7.

Molecular cell - 4 Mar 2005

van der Knaap Jan A, Kumar B R Prashanth, Moshkin Yuri M, Langenberg Karin, Krijgsveld Jeroen, Heck Albert J R, Karch François, Verrijzer C Peter

Abstract excerpt

The packaging of eukaryotic genomic DNA into chromatin is modulated through a range of posttranslational histone modifications. Among these, the role of histone ubiquitylation remains poorly understood. Here, we show that the essential Drosophila ubiquitin-specific protease 7 (USP7) contributes t...

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Source

Identifiers

PMID: 15749019
DOI: 10.1016/j.molcel.2005.02.013

Genes

USP7
GMPS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15749019-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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