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Article

Single-nucleotide polymorphisms in the promoter region of matrix metalloproteinase-1, -2, and -3 in Japanese with high myopia.

Investigative ophthalmology & visual science - 1 Sept 2010

Nakanishi Hideo, Hayashi Hisako, Yamada Ryo, Yamashiro Kenji, Nakata Isao, Shimada Noriaki, Ohno-Matsui Kyoko, Mochizuki Manabu, Ozaki Mineo, Yoshitake Shin, Kuriyama Shoji, Saito Masaaki, Iida Tomohiro, Matsuo Keitaro, Matsuda Fumihiko, Yoshimura Nagahisa

Abstract excerpt

PURPOSE: Polymorphisms in the promoter regions of matrix metalloproteinase (MMP) genes can cause variations in the expression of the MMP genes in the sclera that can lead to a greater susceptibility to axial elongation of the eye. The purpose of this study was to determine whether functional single-nucleotide polymorphisms (SNPs) in the MMP1, -2, and -3 promoter regions are associated with high myopia in the...

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Source

Identifiers

PMID: 20435584
DOI: 10.1167/iovs.09-4871

Genes

MMP1
MMP2
MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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