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Article

Systematic investigation of the relationship between high myopia and polymorphisms of the MMP2, TIMP2, and TIMP3 genes by a DNA pooling approach.

Investigative ophthalmology & visual science - 1 Jun 2011

Leung Kim Hung, Yiu Wai Chi, Yap Maurice K H, Ng Po Wah, Fung Wai Yan, Sham Pak Chung, Yip Shea Ping

Abstract excerpt

PURPOSE: This study examined the relationship between high myopia and three myopia candidate genes--matrix metalloproteinase 2 (MMP2) and tissue inhibitor of metalloproteinase-2 and -3 (TIMP2 and TIMP3)--involved in scleral remodeling. METHODS: Recruited for the study were unrelated adult Han Chinese who were high myopes (spherical equivalent, ≤ -6.0 D in both eyes; cases) and emmetropes (within ±1.0 D in both...

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Source

Identifiers

PMID: 21421877
DOI: 10.1167/iovs.11-7286

Genes

TIMP3
MMP2
TIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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