Article
Myopia and polymorphisms in genes for matrix metalloproteinases.
Investigative ophthalmology & visual science - 1 Jun 2009
Hall Nigel F, Gale Catharine R, Ye Shu, Martyn Christopher N
Abstract excerpt
PURPOSE: To investigate the relation between myopia and variations in three genes coding for matrix metalloproteinases, enzymes that degrade matrix proteins and modulate scleral extensibility. METHODS: Three hundred sixty-six men and women, from Sheffield, United Kingdom, were genotyped for the 1G/2G polymorphism in the MMP-1 gene, the 5A/6A polymorphism in the MMP-3 gene and the Arg-->Gln polymorphism in exon 6...
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