Article
Quantitative analysis of mRNA for 10 different drug resistance factors in dogs with lymphoma.
The Journal of veterinary medical science - 1 Sept 2010
Tomiyasu Hirotaka, Goto-Koshino Yuko, Takahashi Masashi, Fujino Yasuhito, Ohno Koichi, Tsujimoto Hajime
Abstract excerpt
Expression levels of ABCB1, ABCC1, Lung resistance-associated protein (LRP), ABCG2, p53, p21(waf1), Bcl-2, CD40L, glutathione S-transferase alpha (GSTα), and O⁶-methylguanine-DNA-methyltransferase (MGMT) genes, and mutation of p53 gene were examined in 23 dogs with multicentric high-grade lymphoma to explore their association with drug resistance of the tumor cells. Dogs were divided into chemotherapy-sensitive...
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