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Article

Expression of CYP3A4 as a predictor of response to chemotherapy in peripheral T-cell lymphomas

18 Jul 2007

Abstract excerpt

Peripheral T-cell lymphomas (PTCLs) are aggressive tumors in which the current therapy based on multiagent chemotherapy is not successful. Since cytochrome P450 3A subfamily (CYP3A) enzymes are involved in the inactivation of chemotherapy drugs, we hypothesized that CYP3A and P-glycoprotein (MDR1) expression in these lymphomas could result in a poor clinical response. We measured tumoral CYP3A and MDR1 mRNA...

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PMID: 17634410
DOI: 10.1182/blood-2007-02-075036

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