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Article

Loperamide-induced expression of immune and inflammatory genes in Collies associated with ivermectin sensitivity.

Journal of veterinary pharmacology and therapeutics - 1 Apr 2016

Zhu M, Yancy H F, Deaver C, Jones Y L, Myers M J

Abstract excerpt

This study evaluated the impact of the ABCB1-1Δ mutation in Collies which exhibited toxicity toward ivermectin, on changes in gene expression when given the unrelated ABCB1 substrate loperamide, to identify potential biomarkers predictive of drug safety. Thirty-two healthy intact Collies consisting of dogs with either a wild-type, heterozygous mutant, or homozygous mutant genotype were used. Whole blood samples...

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Source

Identifiers

PMID: 26471945
DOI: 10.1111/jvp.12268

Genes

ABCB1
CCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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