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Article

The Expression of P-Glycoprotein in Canine Lymphoma and Its Association with Multidrug Resistance

1 Jan 1995

Abstract excerpt

Canine lymphoma is a spontaneous, naturally occurring disease that is a model for non-Hodgkin's lymphoma in humans. Chemotherapy with antineoplastics results in a high rate of remission; however, relapse and clinical drug resistance are usually seen within 8-10 months. The P-glycoprotein product of the mdr gene is thought to function as an ATP-driven membrane drug efflux pump and appears to play an important role...

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PMID: 7552813
DOI: 10.3109/07357909509024910

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