Article
Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype.
Gene therapy - 1 Sept 2010
Neeson P, Shin A, Tainton K M, Guru P, Prince H M, Harrison S J, Peinert S, Smyth M J, Trapani J A, Kershaw M H, Darcy P K, Ritchie D S
Abstract excerpt
The anti-tumor efficacy of adoptively transferred T cells requires their in vivo persistence and memory polarization. It is unknown if human chimeric antigen receptor (CAR)-expressing T cells can also undergo memory polarization. We examined the functional status of CAR CD8(+) T cells, re-directed to Lewis Y antigen (LeY-T), throughout a period of ex vivo expansion. Immediately before culture CD8(+) T cells...
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