Article
RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation.
The Journal of biological chemistry - 1 Jul 2021
Guo Wenting, Wei Jinhong, Estillore John Paul, Zhang Lin, Wang Ruiwu, Sun Bo, Chen S R Wayne
Abstract excerpt
Ryanodine receptors (RyRs) are ion channels that mediate the release of Ca2+ from the sarcoplasmic reticulum/endoplasmic reticulum, mutations of which are implicated in a number of human diseases. The adjacent C-terminal domains (CTDs) of cardiac RyR (RyR2) interact with each other to form a ring-like tetrameric structure with the intersubunit interface undergoing dynamic changes during channel gating. This...
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