Article
Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity.
The Journal of biological chemistry - 9 Jul 2010
Wang Xiaonan H, Zhang Liping, Mitch William E, LeDoux Joseph M, Hu Junping, Du Jie
Abstract excerpt
With muscle wasting, caspase-3 activation and the ubiquitin-proteasome system act synergistically to increase the degradation of muscle proteins. Whether proteasome activity is also elevated in response to catabolic conditions is unknown. We find that caspase-3 increases proteasome activity in myotubes but not in myoblasts. This difference is related to the cleavage of specific 19 S proteasome subunits. In mouse...
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