Article
Proteasome dysfunction induces muscle growth defects and protein aggregation.
Journal of cell science - 15 Dec 2014
Kitajima Yasuo, Tashiro Yoshitaka, Suzuki Naoki, Warita Hitoshi, Kato Masaaki, Tateyama Maki, Ando Risa, Izumi Rumiko, Yamazaki Maya, Abe Manabu, Sakimura Kenji, Ito Hidefumi, Urushitani Makoto, Nagatomi Ryoichi, Takahashi Ryosuke, Aoki Masashi
Abstract excerpt
The ubiquitin-proteasome and autophagy-lysosome pathways are the two major routes of protein and organelle clearance. The role of the proteasome pathway in mammalian muscle has not been examined in vivo. In this study, we report that the muscle-specific deletion of a crucial proteasomal gene, Rpt3 (also known as Psmc4), resulted in profound muscle growth defects and a decrease in force production in mice....
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