Article
Common variants in CASP3 confer susceptibility to Kawasaki disease.
Human molecular genetics - 15 Jul 2010
Onouchi Yoshihiro, Ozaki Kouichi, Buns Jane C, Shimizu Chisato, Hamada Hiromichi, Honda Takafumi, Terai Masaru, Honda Akihito, Takeuchi Takashi, Shibuta Shoichi, Suenaga Tomohiro, Suzuki Hiroyuki, Higashi Kouji, Yasukawa Kumi, Suzuki Yoichi, Sasago Kumiko, Kemmotsu Yasushi, Takatsuki Shinichi, Saji Tsutomu, Yoshikawa Tetsushi, Nagai Toshiro, Hamamoto Kunihiro, Kishi Fumio, Ouchi Kazunobu, Sato Yoshitake, Newburger Jane W, Baker Annette L, Shulman Stanford T, Rowley Anne H, Yashiro Mayumi, Nakamura Yoshikazu, Wakui Keiko, Fukushima Yoshimitsu, Fujino Akihiro, Tsunoda Tatsuhiko, Kawasaki Tomisaku, Hata Akira, Nakamura Yusuke, Tanaka Toshihiro
Abstract excerpt
Kawasaki disease (KD; OMIM 611775) is an acute vasculitis syndrome which predominantly affects small- and medium-sized arteries of infants and children. Epidemiological data suggest that host genetics underlie the disease pathogenesis. Here we report that multiple variants in the caspase-3 gene (...
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