Article
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.
Nature genetics - 1 Jan 2008
Onouchi Yoshihiro, Gunji Tomohiko, Burns Jane C, Shimizu Chisato, Newburger Jane W, Yashiro Mayumi, Nakamura Yoshikazu, Yanagawa Hiroshi, Wakui Keiko, Fukushima Yoshimitsu, Kishi Fumio, Hamamoto Kunihiro, Terai Masaru, Sato Yoshitake, Ouchi Kazunobu, Saji Tsutomu, Nariai Akiyoshi, Kaburagi Yoichi, Yoshikawa Tetsushi, Suzuki Kyoko, Tanaka Takeo, Nagai Toshiro, Cho Hideo, Fujino Akihiro, Sekine Akihiro, Nakamichi Reiichiro, Tsunoda Tatsuhiko, Kawasaki Tomisaku, Nakamura Yusuke, Hata Akira
Abstract excerpt
Kawasaki disease is a pediatric systemic vasculitis of unknown etiology for which a genetic influence is suspected. We identified a functional SNP (itpkc_3) in the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene on chromosome 19q13.2 that is significantly associated with Kawasaki disease susceptibility and also with an increased risk of coronary artery lesions in both Japanese and US children. Transfection...
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