Article
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
PLoS genetics - 22 Apr 2010
Scherag André, Dina Christian, Hinney Anke, Vatin Vincent, Scherag Susann, Vogel Carla I G, Müller Timo D, Grallert Harald, Wichmann H-Erich, Balkau Beverley, Heude Barbara, Jarvelin Marjo-Riitta, Hartikainen Anna-Liisa, Levy-Marchal Claire, Weill Jacques, Delplanque Jérôme, Körner Antje, Kiess Wieland, Kovacs Peter, Rayner Nigel W, Prokopenko Inga, McCarthy Mark I, Schäfer Helmut, Jarick Ivonne, Boeing Heiner, Fisher Eva, Reinehr Thomas, Heinrich Joachim, Rzehak Peter, Berdel Dietrich, Borte Michael, Biebermann Heike, Krude Heiko, Rosskopf Dieter, Rimmbach Christian, Rief Winfried, Fromme Tobias, Klingenspor Martin, Schürmann Annette, Schulz Nadja, Nöthen Markus M, Mühleisen Thomas W, Erbel Raimund, Jöckel Karl-Heinz, Moebus Susanne, Boes Tanja, Illig Thomas, Froguel Philippe, Hebebrand Johannes, Meyre David
Abstract excerpt
Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new genetic loci for obesity. Here we aimed to discover additional obesity loci in extremely obese children and adolescents. We also investigated if these results generalize by estimating the effects of these obesity loci in adults and in population-based samples including both children and...
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