Article
Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort.
The Journal of clinical endocrinology and metabolism - 1 Apr 2013
Harder Marie N, Ribel-Madsen Rasmus, Justesen Johanne M, Sparsø Thomas, Andersson Ehm A, Grarup Niels, Jørgensen Torben, Linneberg Allan, Hansen Torben, Pedersen Oluf
Abstract excerpt
CONTEXT: Recently, 10 novel type 2 diabetes (T2D) susceptibility single nucleotide polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1, HMG20A, and GRB14 loci were discovered in MetaboChip-genotyped populations of European ancestry. OBJECTIVE: The aim of the present study was to characterize prediabetic quantitative traits underlying these SNP associations and to calculate the amount of...
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