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Article

Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2011

Sarginson Jane E, Killen Joel D, Lazzeroni Laura C, Fortmann Stephen P, Ryan Heather S, Schatzberg Alan F, Murphy Greer M

Abstract excerpt

Stopping smoking is difficult even with treatment. Many patients prescribed pharmacologic treatments for smoking cessation experience side effects or lack of efficacy. We performed a pharmacogenetic study of the efficacy and tolerability of bupropion and transdermal nicotine (TN), two treatments for smoking cessation. Samples were drawn from two studies. In the first study (Maintenance 1, MT1), 301 smokers...

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Topics

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Share to Chromosomes, Human, Pair 15
Share to Demography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multigene Family

Share to Protein Subunits

Share to Receptors, Nicotinic

Share to Regression Analysis

Share to Smoking Cessation

Share to Tobacco Use Disorder

Source

Identifiers

PMID: 21268243
DOI: 10.1002/ajmg.b.31155

Genes

CHRNA5
CHRNA3
CHRNB4

Variants

rs16969968
rs16969968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.PMID 21268243Read ↗

Smoking Cessation Pharmacogenetics: Analysis of Varenicline and Bupropion in Placebo-Controlled Clinical TrialsSemantic proximity Read ↗

Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity.Semantic proximity Read ↗

Pharmacogenetic study of seven polymorphisms in three nicotinic acetylcholine receptor subunits in smoking-cessation therapies.Semantic proximity Read ↗

Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women.Semantic proximity Read ↗

Response to Transdermal Selegiline Smoking Cessation Therapy and Markers in the 15q24 Chromosomal Region.Semantic proximity Read ↗

A systematic review of genetic variation within nicotinic acetylcholine receptor genes and cigarette smoking cessation.Semantic proximity Read ↗

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Semantic proximity Read ↗

Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.Semantic proximity Read ↗

Impact of genetic variability in nicotinic acetylcholine receptors on nicotine addiction and smoking cessation treatment.Semantic proximity Read ↗

Meta-analysis and imputation refines the association of 15q25 with smoking quantity.Semantic proximity Read ↗

Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.Semantic proximity Read ↗

Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.Semantic proximity Read ↗

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