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Article

Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster.

Chemistry & biology - 23 Apr 2010

Circello Benjamin T, Eliot Andrew C, Lee Jin-Hee, van der Donk Wilfred A, Metcalf William W

Abstract excerpt

Dehydrophos is a vinyl phosphonate tripeptide produced by Streptomyces luridus with demonstrated broad-spectrum antibiotic activity. To identify genes necessary for biosynthesis of this unusual compound we screened a fosmid library of S. luridus for the presence of the phosphoenolpyruvate mutase gene, which is required for biosynthesis of most phosphonates. Integration of one such fosmid clone into the chromosome...

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Identifiers

PMID: 20416511
DOI: 10.1016/j.chembiol.2010.03.007
PMCID: PMC2888486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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