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Article

Creation of a shikimate pathway variant.

Journal of the American Chemical Society - 9 Jun 2004

Ran Ningqing, Draths K M, Frost J W

Abstract excerpt

The competition between the Escherichia coli carbohydrate phosphotransferase system and 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAHP) synthase for phosphoenolpyruvate limits the concentration and yield of natural products microbially synthesized via the shikimate pathway. To circumvent this competition for phosphoenolpyruvate, a shikimate pathway variant has been created. 2-Keto-3-deoxy-6-phosphogalactonate...

Topics

Aldehyde-Lyases
Directed Molecular Evolution
Escherichia coli
Klebsiella pneumoniae
Mutation
Shikimic Acid

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15174841
DOI: 10.1021/ja049730n

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