Article
Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis.
Molecular & general genetics : MGG - 27 Nov 1995
Hidaka T, Goda M, Kuzuyama T, Takei N, Hidaka M, Seto H
Abstract excerpt
The biosynthetic pathway for production of the antibiotic fosfomycin by Streptomyces wedmorensis consists of four steps including the formation of a C-P bond and an epoxide. Fosfomycin production genes were cloned from genomic DNA using S. wedmorensis mutants blocked at different steps of the bio...
Topics
- Acetaldehyde
- Amino Acid Sequence
- Aminoethylphosphonic Acid
- Base Sequence
- Cloning, Molecular
- Fosfomycin
- Molecular Sequence Data
- Multigene Family
- Mutation
- Phosphoenolpyruvate
- Phosphotransferases (Phosphomutases)
- Plasmids
- Restriction Mapping
- Sequence Homology, Amino Acid
- Streptomyces