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Article

Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement.

Journal of bacteriology - 1 May 1993

MacNeil T, Gewain K M, MacNeil D J

Abstract excerpt

Streptomyces avermitilis produces a group of glycosylated, methylated macrocyclic lactones, the avermectins, which have potent anthelmintic activity. A homologous recombination strategy termed gene cluster displacement was used to construct Neor deletion strains with defined endpoints and to clone the corresponding complementary DNA encoding functions for avermectin biosynthesis (avr). Thirty-five unique...

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Identifiers

PMID: 8478321
DOI: 10.1128/jb.175.9.2552-2563.1993
PMCID: PMC204556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement.PMID 8478321Read ↗

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Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component.Semantic proximity Read ↗

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