Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SVA retrotransposons: Evolution and genetic instability.

Seminars in cancer biology - 1 Aug 2010

Hancks Dustin C, Kazazian Haig H

Abstract excerpt

SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are associated with disease in humans. SVAs are evolutionarily young and presumably mobilized by the LINE-1 reverse transcriptase in trans. SVAs are currently active and may impact the host through a variety of mechanisms including insertional mutagenesis, exon shuffling, alternative splicing, and the generation of differentially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alu Elements
Share to Evolution, Molecular
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Genomic Instability

Share to Minisatellite Repeats

Share to Models, Biological

Share to Short Interspersed Nucleotide Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 20416380
DOI: 10.1016/j.semcancer.2010.04.001
PMCID: PMC2945828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SVA retrotransposons: Evolution and genetic instability.PMID 20416380Read ↗

The impact of retrotransposons on human genome evolution.Semantic proximity Read ↗

Active human retrotransposons: variation and disease.Semantic proximity Read ↗

Hominid retrotransposons as a modulator of genomic functionSemantic proximity Read ↗

5'-Transducing SVA retrotransposon groups spread efficiently throughout the human genome.Semantic proximity Read ↗

The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes.Semantic proximity Read ↗

Genetic and epigenetic variations contributed by Alu retrotransposition.Semantic proximity Read ↗

Retroelements in human disease.Semantic proximity Read ↗

Retrotransposon life cycle and its impacts on cellular responsesSemantic proximity Read ↗

A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegenerationSemantic proximity Read ↗

SVA retrotransposons as potential modulators of neuropeptide gene expression.Semantic proximity Read ↗

Transposable element-driven transcript diversification and its relevance to genetic disorders.Semantic proximity Read ↗

Mobile elements and mammalian genome evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.