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Article

Architecture of inherited susceptibility to common cancer.

Nature reviews. Cancer - 1 May 2010

Fletcher Olivia, Houlston Richard S

Abstract excerpt

This Timeline article looks back at 40 years of research into the inherited genetic basis of cancer and the insights these studies have yielded. Early epidemiological research provided evidence for the 'two-hit' model of cancer predisposition. During the 1980s and 1990s linkage and positional cloning analyses led to the identification of high-penetrance cancer susceptibility genes. The past decade has seen a...

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PMID: 20414203
DOI: 10.1038/nrc2840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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