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Article

Inherited Susceptibility to Cancer: Past, Present and Future.

Annals of human genetics - 1 Sept 2025

Hodgson Shirley V, Foulkes William D, Maher Eamonn R, Turnbull Clare

Abstract excerpt

Germline pathogenic variants (GPVs, 'mutations') causing inherited susceptibility to certain cancers (cancer susceptibility genes, CSGs) broadly belong to one of two main classes-loss of function variants in tumour suppressor genes (TSGs) or gain of function variants in proto-oncogenes (an over-simplification). Genomic analyses of tumours identify 'driver mutations' promoting tumour growth and somatic variants...

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Identifiers

PMID: 40689426
DOI: 10.1111/ahg.70013
PMCID: PMC12336944

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