Article
Genetics of cancer predisposition and progression.
The Clinical investigator - 1 Jun 1993
Schwechheimer K, Cavenee W K
Abstract excerpt
The development of human cancer is a multistep process that entails a progressively more malignant phenotype through the evolution of cellular subsets with increasing numbers of genetic alterations. Here we review the molecular genetics of human cancer predisposition and progression and describe...
Topics
- Cell Transformation, Neoplastic
- Genes, Dominant
- Genes, Recessive
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Humans
- Mutation
- Neoplasms
- Neoplastic Syndromes, Hereditary
- Oncogenes
- Proto-Oncogenes
- Sequence Deletion