Article
Overview: genes that predispose to cancer.
Mutation research - 1 Apr 1991
Knudson A G
Abstract excerpt
Heredity and environment both operate in the origin of cancer. Dominantly heritable cancer is caused by 'cancer' genes that impart high relative risks but account for only a small part of the incidence of cancer; they are usually recessive in oncogenesis, mutation or loss of the second allele being necessary. Non-hereditary forms of cancer may involve the same genes. Other genes interact with environment in...
Topics
- Cell Transformation, Neoplastic
- Environment
- Genes, Tumor Suppressor
- Mutation
- Neoplasms
- Oncogenes