Cancer genes: single and susceptibility: exposing the difference.

Abstract excerpt

'Single' genes, necessary and sufficient to cause cancer, are contrasted with 'susceptibility' genes that are neither, but may act in the presence of specific environmental exposures to alter the chances of cancer in the host. The former are rare, are of high absolute and relative risks, have minimal dependence on exposures and therefore have low population attributable risks. A small number of such genes are...

Topics

• Environmental Exposure
• Genetic Predisposition to Disease
• Humans
• Neoplasms
• Oncogenes
• Risk Factors