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Article

Disruption of Igfbp1 fails to rescue the phenotype of Sirt1-/- mice.

Experimental cell research - 1 Aug 2010

Boily Gino, He Xiao Hong, Jardine Karen, McBurney Michael W

Abstract excerpt

Sirtuin 1 (SIRT1) is an NAD-dependent histone deacetylase (HDAC) whose activity is thought to forestall the onset of a variety of age-related diseases. Mice carrying null mutations of the Sirt1 gene suffer high rates of neonatal lethality and those that survive are sterile, growth retarded, lean and their livers express high levels of insulin-like growth factor binding protein-1 (IGFBP1). IGFBP1 binds and...

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Source

Identifiers

PMID: 20412791
DOI: 10.1016/j.yexcr.2010.04.012

Genes

IGFBP1
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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