Article
Modulating numbers and phenotype of CD8+ T cells in secondary immune responses.
European journal of immunology - 1 Jul 2010
Wirth Thomas C, Harty John T, Badovinac Vladimir P
Abstract excerpt
Prime-boost regimens are frequently used to increase the number of memory CD8(+) T cells and thus the protective capacity of experimental vaccinations; however, it is currently unknown how the frequency and phenotype of primary (1 degrees ) memory CD8(+) T cells impact the quantity and phenotype of secondary (2 degrees ) memory CD8(+) T-cell populations. Here, we show that 2 degrees infections of mice that...
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