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Article

Large-scale Sequencing of Testicular Germ Cell Tumour (TGCT) Cases Excludes Major TGCT Predisposition Gene.

European urology - 1 Jun 2018

Litchfield Kevin, Loveday Chey, Levy Max, Dudakia Darshna, Rapley Elizabeth, Nsengimana Jeremie, Bishop D Tim, Reid Alison, Huddart Robert, Broderick Peter, Houlston Richard S, Turnbull Clare

Abstract excerpt

Testicular germ cell tumour (TGCT), the most common cancer in young men, has a significant heritable basis that has long raised questions as to the existence of underlying major high-penetrance susceptibility gene(s). To determine the contribution of rare gene mutations to the inherited risk of TGCT, we analysed germline whole-exome data for 919 TGCT cases and 1609 cancer-free controls. We compared frequencies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29433971
DOI: 10.1016/j.eururo.2018.01.021

Genes

BRCA1

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