Article
Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells.
Haematologica - 1 Sept 2009
Akagi Tadayuki, Shih Lee-Yung, Ogawa Seishi, Gerss Joachim, Moore Stephen R, Schreck Rhona, Kawamata Norihiko, Liang Der-Cherng, Sanada Masashi, Nannya Yasuhito, Deneberg Stefan, Zachariadis Vasilios, Nordgren Ann, Song Jee Hoon, Dugas Martin, Lehmann Sören, Koeffler H Phillip
Abstract excerpt
Translocation of chromosomes 8 and 21, t(8;21), resulting in the AML1-ETO fusion gene, is associated with acute myeloid leukemia. We searched for additional genomic abnormalities in this acute myeloid leukemia subtype by performing single nucleotide polymorphism genomic arrays (SNP-chip) analysis on 48 newly diagnosed cases. Thirty-two patients (67%) had a normal genome by SNP-chip analysis (Group A), and 16...
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