Article
Mutation of the RDR1 gene caused genome-wide changes in gene expression, regional variation in small RNA clusters and localized alteration in DNA methylation in rice.
BMC plant biology - 30 Jun 2014
Wang Ningning, Zhang Di, Wang Zhenhui, Xun Hongwei, Ma Jian, Wang Hui, Huang Wei, Liu Ying, Lin Xiuyun, Li Ning, Ou Xiufang, Zhang Chunyu, Wang Ming-Bo, Liu Bao
Abstract excerpt
BACKGROUND: Endogenous small (sm) RNAs (primarily si- and miRNAs) are important trans/cis-acting regulators involved in diverse cellular functions. In plants, the RNA-dependent RNA polymerases (RDRs) are essential for smRNA biogenesis. It has been established that RDR2 is involved in the 24 nt siRNA-dependent RNA-directed DNA methylation (RdDM) pathway. Recent studies have suggested that RDR1 is involved in a...
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