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Article

Modeling of protrusion phenotypes driven by the actin-membrane interaction.

Biophysical journal - 21 Apr 2010

Enculescu Mihaela, Sabouri-Ghomi Mohsen, Danuser Gaudenz, Falcke Martin

Abstract excerpt

We propose a mathematical model for simulating the leading-edge dynamics of a migrating cell from the interplay among elastic properties, architecture of the actin cytoskeleton, and the mechanics of the membrane. Our approach is based on the description of the length and attachment dynamics of actin filaments in the lamellipodium network. It is used to determine the total force exerted on the membrane at each...

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Identifiers

PMID: 20409477
DOI: 10.1016/j.bpj.2009.12.4311
PMCID: PMC2856167

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