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Article

Risk of breast and prostate cancer is not associated with increased homozygosity in outbred populations.

European journal of human genetics : EJHG - 1 Aug 2010

Enciso-Mora Victor, Hosking Fay J, Houlston Richard S

Abstract excerpt

Regions of restricted genetic heterogeneity due to identity by descent (autozygosity) are known to confer susceptibility to a number of diseases. Regions of germline homozygosity (ROHs) of 1-2 Mb, the result of autozygosity, are detectable at high frequency in outbred populations. Recent studies have reported that ROHs, possibly through exposing recessive disease-causing alleles or alternative mechanisms, are...

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Identifiers

PMID: 20407466
DOI: 10.1038/ejhg.2010.53
PMCID: PMC2987391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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