Regions of homozygosity identified by oligonucleotide SNP arrays: evaluating the incidence and clinical utility.

doi:10.1038/ejhg.2014.153

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Article

Regions of homozygosity identified by oligonucleotide SNP arrays: evaluating the incidence and clinical utility.

European journal of human genetics : EJHG - 1 May 2015

Wang Jia-Chi, Ross Leslie, Mahon Loretta W, Owen Renius, Hemmat Morteza, Wang Boris T, El Naggar Mohammed, Kopita Kimberly A, Randolph Linda M, Chase John M, Matas Aguilera Maria J, Siles Juan López, Church Joseph A, Hauser Natalie, Shen Joseph J, Jones Marilyn C, Wierenga Klaas J, Jiang Zhijie, Haddadin Mary, Boyar Fatih Z, Anguiano Arturo, Strom Charles M, Sahoo Trilochan

Abstract excerpt

Copy neutral segments with allelic homozygosity, also known as regions of homozygosity (ROHs), are frequently identified in cases interrogated by oligonucleotide single-nucleotide polymorphism (oligo-SNP) microarrays. Presence of ROHs may be because of parental relatedness, chromosomal recombination or rearrangements and provides important clues regarding ancestral homozygosity, consanguinity or uniparental...

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PMID: 25118026
DOI: 10.1038/ejhg.2014.153
PMCID: PMC4402629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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