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Article

Frequency of germline genomic homozygosity associated with cancer cases.

JAMA - 26 Mar 2008

Assié Guillaume, LaFramboise Thomas, Platzer Petra, Eng Charis

Abstract excerpt

CONTEXT: Cancer is a multigenic disease resulting from both germline susceptibility and somatic events. While studying loss of heterozygosity (LOH) in cancer tissues, we anecdotally observed a low frequency of heterozygosity in cancer patients compared with controls, raising the question whether homozygosity could play a role in cancer predisposition. OBJECTIVES: To determine the frequency of germline...

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Identifiers

PMID: 18364486
DOI: 10.1001/jama.299.12.1437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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